The SpaceX Dragon capsule undocked from the International Space Station and splashed down in the Pacific after spending three weeks in space.
It undocked at 9:29 a.m. Sunday above the country of Myanmar and splashed down in the Pacific Ocean at 3:22 p.m.
The capsule had been docked with the ISS since Oct. 10 after blasting off aboard the Falcon 9 rocket from the Space Coast three days earlier on a re-supply mission.
It's the first of 12 missions as part of NASA's plan to work with private space companies.
The Dragon carried more than 1,000 pounds of cargo, including food and clothing for the crew, student experiments and a freezer holding chilled experiments, which the crew will perform while in orbit.
Astronauts loaded the capsule back up with more experiments, including hundreds of blood and urine samples NASA scientists will use to determine the effects space has on the human body.
"It was nice while she was on board, we tamed her, took her home," said Sunita Williams, an astronaut on board the ISS. "And literally and figuratively there is a piece of us on that spacecraft going home to Earth."
These were the first experiments brought back since the shuttle fleet retired last year.
The next SpaceX rocket mission is set for mid-January from the Cape.